New Book Explores the Benefits and Risks of Ibuprofen

A recent publication sheds light on the multifaceted effects of ibuprofen, one of the most commonly used over-the-counter pain relievers worldwide. Led by Professor Aldrin Gomes from UC Davis, along with a team of 36 students and researchers, the book offers an in-depth examination of both the positive and negative impacts of this widely utilized medication.

Ibuprofen has revolutionized pain management, providing an affordable and accessible remedy for headaches, fever, and inflammation. However, beneath its widespread use lies a complex profile of potential health risks. Studies have indicated that regular, daily use of ibuprofen may increase the risk of stroke by threefold, with other research suggesting rises of 10% to 50% in stroke risk shortly after initiation of treatment. The medication is also associated with other adverse effects, including heart attack, heart failure, and gastrointestinal bleeding.

Beyond individual health impacts, ibuprofen interacts with over 400 prescription drugs, posing risks of drug interactions. Environmental concerns are also highlighted, as discarded pills can be toxic to pets and aquatic ecosystems, affecting fish and plant life.

The motivation behind the book stemmed from Gomes’ observations that students entering his lab often lacked awareness of ibuprofen’s potential negative effects. To address this knowledge gap, the project became a collaborative effort involving students in research, writing, editing, and illustrating. The process has not only enhanced their understanding of pharmacology but also emphasized the importance of science communication.

The book covers how ibuprofen functions to alleviate pain, reduce inflammation, and bring down fevers. It discusses how the medication can impact vital organs such as the heart, liver, kidneys, and gastrointestinal system. Importantly, it offers guidance on responsible use of painkillers and explores natural alternatives for pain management.

Published on June 3 by Mystic River Books, "The Comprehensive Guide to Ibuprofen: The Good, the Bad and the Unexpected" is available in various formats including e-book, paperback, and hardcover. The publication aims to educate the public about the balanced benefits and risks associated with this essential drug.

For more information, the original article can be referenced at https://medicalxpress.com/news/2025-06-good-bad-unexpected-ibuprofen.html