Cinnamon's Impact on Drug Metabolism and Potential Herb-Drug Interactions

Cinnamon, a widely used spice with a rich history in culinary and traditional medicine, may have effects beyond flavoring foods. Recent research conducted by scientists at the University of Mississippi's National Center for Natural Products Research highlights that a compound in cinnamon called cinnamaldehyde can influence how the body processes certain medications. Published in Food Chemistry: Molecular Sciences, the study found that cinnamaldehyde activates specific receptors responsible for regulating the metabolic clearance of drugs. This activation could potentially reduce the effectiveness of some prescription medications if large amounts of cinnamon or cinnamon supplements are consumed without medical supervision.

The scientists emphasize that overconsumption of cinnamon supplements could lead to a faster elimination of drugs from the body, thereby diminishing their therapeutic effects. While typical culinary use, such as sprinkling cinnamon on coffee or desserts, is unlikely to cause issues, high-dose supplement use warrants caution. The primary component, cinnamaldehyde, affects xenobiotic receptors involved in drug metabolism, making it vital to understand its interaction with prescribed medications.

Not all cinnamon products pose the same risks. Cinnamon oil, often applied topically for antifungal and antibacterial purposes, generally does not interfere with medications. Conversely, Cassia cinnamon, a common grocery store variety from southern China, contains high levels of coumarin—a natural compound that can thin blood and pose risks for individuals on blood-thinning therapies. True cinnamon from Sri Lanka has lower coumarin levels and a reduced risk of adverse effects.

Experts indicate that more clinical studies are necessary to fully comprehend cinnamon’s role in drug interactions. Until definitive evidence is available, healthcare professionals recommend that individuals, especially those with chronic health conditions like hypertension, diabetes, or heart disease, consult their doctors before using cinnamon supplements. This precaution is essential because dietary supplements are not meant to replace medical treatments and should be used carefully alongside prescribed medications.

Overall, while cinnamon has beneficial properties, its potential to interfere with drug metabolism underscores the importance of moderation and medical guidance when considering high-dose intake or supplementation.

Source: https://medicalxpress.com/news/2025-04-cinnamon-affect-drug-metabolism-body.html