Research Links Childhood Health Factors to Men’s Risk of Chronic Diseases in Later Life

Recent research underscores the importance of childhood health in determining long-term health outcomes for men. Scientists from the University of Nottingham's School of Biosciences analyzed data from the 'Children of the Nineties' cohort, following males from birth into their twenties. They focused on the hormone biomarker insulin-like peptide 3 (INSL3), which reflects testicular capacity to produce testosterone—a hormone vital for reproduction and overall health.

The study revealed that certain childhood health factors significantly influence INSL3 levels in adulthood, which are linked to risks of chronic diseases such as diabetes, cardiovascular conditions, bone weakness, and sexual dysfunction. Notably, being overweight during childhood or adolescence, and experiencing chickenpox or other infections in infancy, were associated with a 10-15% reduction in adult INSL3 levels, suggesting a heightened vulnerability to these health issues later in life.

This groundbreaking research, published in Andrology, is the first to examine how early-life diet, health, and infections impact long-term health across the lifespan. Dr. Ravinder Anand-Ivell and colleagues emphasize that low levels of INSL3 in young men reflect diminished testicular function, which can have lasting effects.

Using data from the Avon Longitudinal Study, the team identified that childhood overweight status and infectious diseases are critical determinants of future health. The findings highlight the potential of INSL3 as a predictive biomarker for early identification of men at risk of developing chronic health problems. The next step involves developing clinical tests to measure INSL3 routinely, enabling early interventions to promote healthy aging.

Overall, this study reinforces the significance of early childhood health and vaccination in shaping men’s health trajectories and underscores the need for preventative strategies from a young age.

Source: https://medicalxpress.com/news/2025-07-link-childhood-health-disease-men.html