Impact of Cardiovascular, Kidney, and Metabolic Health on Psoriasis Risk

Recent research has revealed a significant link between poor cardiovascular, kidney, and metabolic (CKM) health and an increased risk of developing psoriasis. The study highlights that individuals with compromised CKM health—characterized by factors such as chronic kidney disease, cardiovascular issues, and metabolic disturbances—are more prone to psoriasis, especially if they possess a high genetic predisposition.

The research, conducted by Gang Zheng and colleagues from China Medical University and utilizing data from the UK Biobank involving over 390,000 participants, categorizes CKM health into five stages. The findings show that the hazard ratios for developing psoriasis rise progressively with worsening CKM stages: 1.21, 1.38, 1.64, and 1.72 for stages 1 through 4, respectively, compared to stage 0. Notably, participants with stage 4 CKM health and high genetic risk faced up to a 2.82-fold increased risk of psoriasis.

Furthermore, there was a notable additive interaction between advanced CKM stages and high genetic risk, emphasizing the compounded effect on psoriasis susceptibility. Advanced CKM health also correlated with a reduction in life expectancy—by approximately 2 years within the psoriasis-affected population.

These findings underscore the importance of early detection and intervention in CKM health to prevent psoriasis and improve overall longevity. Addressing metabolic and cardiovascular risks at initial stages could be a crucial step in reducing the burden of psoriasis and associated health complications.

For more detailed insights, the full study is published in the Journal of the European Academy of Dermatology and Venereology: DOI: 10.1111/jdv.20852.