Innovative Brain Training Game Shows Promise for Non-Drug Pain Relief

A recent breakthrough in pain management involves an interactive brain training game designed to help individuals regulate abnormal brain activity linked to chronic nerve pain. Developed by researchers at UNSW Sydney, this non-invasive, at-home therapy aims to reduce pain without reliance on medication like opioids. The technology, called PainWaive, utilizes EEG headsets and a specially designed app that guides users through mental strategies such as relaxing or focusing on positive memories. Participants' brain activity is monitored remotely, and the system responds in real time to normalize neural patterns associated with neuropathic pain.

A preliminary trial led by Professor Sylvia Gustin and Dr. Negin Hesam-Shariati demonstrated significant pain reduction in three out of four participants after four weeks of game play. The reductions were comparable to, or greater than, those achieved with opioids. The intervention targets specific brain wave patterns—such as excessive slow theta waves and high beta waves—that disrupt communication between the thalamus and sensory regions involved in pain perception.

The team developed a cost-effective, lightweight headset using a saline-based electrode system, made affordable through 3D printing, with a price around $300—much lower than conventional EEG systems. Participants found the device comfortable and simple to use, empowering them to manage their pain independently.

While larger studies are necessary to confirm these findings, the initial results are promising. Researchers are now seeking volunteers for upcoming trials targeting spinal pain and neuropathic pain in spinal injury patients. This technology represents a significant step toward accessible, drug-free pain treatment options and underscores the potential of neurofeedback and brainwave normalization in managing chronic pain.

Source: https://medicalxpress.com/news/2025-06-brain-game-drug-free-pain.html