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How the Brain Differentiates Between Ambiguous Hypotheses During Navigation

How the Brain Differentiates Between Ambiguous Hypotheses During Navigation

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MIT researchers have identified neural activity patterns in the retrosplenial cortex that represent multiple hypotheses during navigation, shedding light on how the brain resolves ambiguity in complex environments.

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Navigating environments where landmarks are unclear or confusing requires complex cognitive processes in the brain. When faced with ambiguous landmarks—such as identical or similar features—our brain must hold multiple hypotheses about our location until sufficient information clarifies our position. Recent research from MIT has uncovered how neural activity patterns in the retrosplenial cortex (RSC) explicitly represent these multiple hypotheses simultaneously, a groundbreaking discovery in understanding complex reasoning and navigation.

In a study involving mice, scientists observed that the RSC doesn't just passively store information but actively encodes different possible locations or hypotheses about where the animal might be. During navigation tasks involving ambiguous landmarks, neural populations in the RSC displayed distinct activity patterns corresponding to different hypotheses. As mice approached and gathered more visual and spatial information, these patterns converged into a single, correct hypothesis, guiding the animal to the reward.

This research is the first to provide evidence that the brain holds multiple hypotheses in working memory and utilizes this information dynamically to make decisions. It demonstrates that neural representations in the RSC enable animals to differentiate between ambiguous visual cues by holding and processing competing hypotheses, a process crucial for flexible navigation in complex environments.

The findings also align with computational models where interconnected neural networks—both biological and artificial—exhibit similar activity patterns. These models suggest that complex dynamics in neural networks are essential for processing multiple hypotheses simultaneously.

Further investigations by MIT researchers will explore how other brain regions involved in navigation, such as the prefrontal cortex, contribute to these processes, especially under naturalistic conditions where animals are not trained but explore freely. This work enhances our understanding of how brains implement reasoning and decision-making in uncertain situations, with implications for understanding human navigation, cognition, and disorders affecting these functions.

Source: Medical Xpress

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