New Research Links Blood Proteins to Alzheimer's Disease and Memory Decline

Recent research conducted by scientists at Emory University’s Goizueta Brain Health Institute has uncovered significant new insights into the role of blood proteins in the development of Alzheimer's disease and its impact on memory. The study analyzed blood samples from over 2,100 participants across multiple large cohorts, employing advanced proteomic tools to measure thousands of proteins. The research revealed that elements related to immune response, protein disposal, energy metabolism, and extracellular matrix support are linked to cognitive decline and memory problems associated with Alzheimer's. Interestingly, many of these protein changes do not directly correspond with the typical brain changes seen in Alzheimer’s, such as amyloid plaques, suggesting that systemic factors outside of the brain may influence disease progression. Dr. Erik Johnson emphasizes that the proteins identified in blood could reflect body-wide processes contributing to Alzheimer’s risk and speed of progression, opening new avenues for treatment strategies directed at blood-based pathways. The findings also support the potential for blood tests to serve as less invasive, more accessible methods for early detection and monitoring of Alzheimer’s disease, moving beyond traditional focus solely on brain pathology. This research leveraged data from various studies, including those from Emory University, Bio-Hermes, and the Rush Memory and Aging Project, paving the way for innovative approaches in diagnosis and therapy. For more detailed information, see the publication in Nature Aging (2025). source: https://medicalxpress.com/news/2025-09-links-blood-proteins-alzheimer-disease.html