Arginine Toothpaste Shows Promise in Reducing Childhood Cavities
A two-year clinical trial demonstrates that arginine-containing toothpaste can significantly reduce dental cavities in children, offering a promising alternative to fluoride-based products.
A recent clinical trial published in JDR Clinical & Translational Research highlights the effectiveness of arginine-containing dentifrices in managing childhood dental caries. The study, conducted over two years across three centers in China, involved 6,000 children aged 10 to 14 who had multiple active cavities. Participants were assigned to use one of three types of toothpaste: 8.0% arginine, 1.5% arginine, or 0.32% sodium fluoride (NaF) as a control.
Results revealed that the toothpaste with 8.0% arginine significantly reduced the number of decayed, missing, and filled surfaces (DMFS) by 26.0%, and decayed, missing, and filled teeth (DMFT) by 25.3%, compared to the NaF control group. In contrast, the 1.5% arginine formulation showed no significant difference from the fluoride control.
These findings indicate that higher concentrations of arginine in toothpaste can be as effective or even more effective than traditional fluoride-based products in preventing dental decay among children with active cavities. While fluoride remains a cornerstone of caries prevention, this research suggests that arginine-based dentifrices could serve as a valuable alternative or complement, especially for populations at higher risk of dental decay.
Further research into optimal concentrations and long-term effects could pave the way for new, more effective oral health strategies. This study underscores the potential of alternative active ingredients in dental care, promoting better oral health outcomes for children worldwide.
Source: https://medicalxpress.com/news/2025-08-arginine-dentifrices-significantly-childhood-caries.html
Stay Updated with Mia's Feed
Get the latest health & wellness insights delivered straight to your inbox.
Related Articles
Europe Faces its Largest Diphtheria Outbreak in Seven Decades
Europe is experiencing its largest diphtheria outbreak in 70 years, mainly affecting migrants and vulnerable populations. Experts stress the importance of vaccination and public health measures to control the spread of this contagious disease.
Guidelines from Leading Societies for Transcatheter Left Atrial Appendage Occlusion in Stroke Prevention
New evidence-based guidelines from SCAI and HRS provide standardized recommendations for transcatheter left atrial appendage occlusion, a key stroke prevention strategy in non-valvular atrial fibrillation, addressing patient selection, imaging, and complication management.
Elevating Potassium Levels May Reduce Risks in High-Risk Cardiac Patients
New research suggests that maintaining higher-normal potassium levels can significantly lower the risk of ventricular arrhythmias and improve outcomes in high-risk cardiac patients, offering a simple and cost-effective treatment approach.
Innovative Nanovesicle Formulation Enhances Cancer Drug Delivery and Efficacy
A newly developed nanovesicle formulation of paclitaxel improves targeted delivery to tumors, reduces side effects, and enhances the efficacy of combination cancer therapies, paving the way for advanced treatment options.