Innovative 'Montreal Model' Enhances Durability of Ketamine-Based Depression Treatment
The Montreal Model of ketamine therapy combines psychotherapy and supportive environments, leading to more sustained relief from severe depression and treatment resistance.
Recent clinical research led by McGill University introduces the 'Montreal Model,' a novel approach to ketamine therapy for severe depression. The study demonstrates that combining ketamine infusions with psychotherapy and a therapeutic environment significantly extends the duration of antidepressant effects. Participants with treatment-resistant depression, many experiencing suicidal thoughts, showed an average depression score reduction of approximately 30%, with improvements in suicidality and anxiety. Notably, these effects persisted for at least eight weeks, unlike conventional ketamine treatments where benefits often diminish within days.
The study emphasizes the importance of the treatment environment—rooms designed with calming lighting, plants, curated music or guided mindfulness—alongside regular psychotherapy sessions. This approach underscores the significance of psychological context in treatment outcomes.
Developed during residencies at McGill by Dr. Greenway and Dr. Garel, the Montreal Model integrates traditional psychiatry with strategies inspired by psychedelic therapy, including creating safe, supportive spaces for patients. The model has been successfully applied in both public and private healthcare settings in Canada and internationally.
An intriguing aspect of the research is the link between the subjective mystical or emotional experiences during ketamine sessions and positive therapeutic outcomes. These findings challenge the traditional view of such experiences as mere side effects, suggesting they may be integral to the healing process.
The study's positive results support the adoption of structured, environment-centric ketamine treatments, offering a promising path for managing complex, treatment-resistant depression. It also highlights the need for standardized protocols as ketamine clinics proliferate across Canada and beyond.
For further information, see the original source at
https://medicalxpress.com/news/2025-06-montreal-ketamine-therapy-yields-sustained.html
source: https://medicalxpress.com/news/2025-06-montreal-ketamine-therapy-yields-sustained.html
Stay Updated with Mia's Feed
Get the latest health & wellness insights delivered straight to your inbox.
Related Articles
Children Born Late in the Year Face Increased Risk of Mental Health Challenges
Children born late in the year, especially those born prematurely, face higher risks of mental health issues, including ADHD and emotional disorders. A Norwegian study suggests the need for educational adjustments to support vulnerable students.
The Impact of RFK Jr.'s Advocacy on the Future of Psychedelic Therapy
RFK Jr.'s push for accelerated approval of psychedelic therapies could transform mental health treatment, but experts caution the need for rigorous science to ensure safety and credibility.
Collaborative Approach Key to Tackling Childhood Anxiety and Depression
Research highlights the effectiveness of family-centered therapies like BEST-F in reducing childhood anxiety and depression by involving parents and caregivers, promoting lasting emotional health improvements.
Vietnamese Lung Cancer Caregivers Suffer from Low Resilience and Mental Health Struggles
A groundbreaking study in Vietnam reveals that over 50% of family caregivers for lung cancer patients have low resilience, risking mental health and facing significant emotional strain amidst limited support systems.