Natural Compound Blocks New Cancer Cell Energy Pathway Identified

Researchers from Osaka Metropolitan University have uncovered a promising natural compound that can interfere with a novel energy pathway used by certain cancer cells. The compound, ethyl p-methoxycinnamate, a key component of kencur ginger, was shown to inhibit the production of ATP—the energy molecule vital for cell survival—by disrupting fatty acid synthesis and lipid metabolism. Interestingly, instead of targeting glycolysis, which is the common energy source in cancer cells, this compound affects alternative metabolic routes. When exposed to ethyl p-methoxycinnamate, cancer cells increased glycolytic activity as a survival response, indicating an adaptive mechanism that prevents cell death. These insights expand our understanding of cancer metabolism, particularly the Warburg effect, and open new avenues for therapeutic strategies. The study suggests that targeting fatty acid synthesis pathways could be an effective approach in cancer treatment, especially given the compound's ability to cripple ATP production without inducing apoptosis. The findings highlight the importance of exploring natural substances for novel anti-cancer agents and contribute to the growing field of cancer metabolism research.