Link Between Metabolic Liver Disease and Increased Risk of Sudden Hearing Loss

Recent research has identified a significant association between metabolic dysfunction-associated steatotic liver disease (MASLD) and the heightened risk of sudden sensorineural hearing loss (SSNHL) among older adults. The study, published in the June issue of Laryngoscope: Investigative Otolaryngology, examined a large cohort of individuals aged 65 and above to understand how metabolic liver health impacts auditory function.

MASLD, a condition characterized by fat accumulation in the liver linked to metabolic issues, was evaluated in a population-based study utilizing data from the Korean National Health Insurance Service-Senior cohort. The study involved 189,623 participants who were categorized based on the presence or absence of MASLD. Researchers observed markers of metabolic health, including body mass index, waist circumference, and blood pressure, which tend to be elevated in individuals with MASLD.

Over a follow-up period of nine years, there were 3,803 reported cases of SSNHL within the MASLD group. This group showed an incidence rate of 2.44 per 1,000 person-years. After adjusting for various factors, the study concluded that individuals with MASLD had a modest but statistically significant increased risk of developing sudden hearing loss. The findings suggest that MASLD is not only a liver condition but also a potential indicator of overall disease progression, including neurovascular health.

The researchers emphasize that these insights highlight the importance of metabolic health management, especially in aging populations, to possibly prevent or mitigate sudden hearing loss. Healthcare professionals are encouraged to consider liver health and metabolic markers when assessing risks for audiological issues in older adults.

This study underscores the interconnectedness of metabolic disorders and sensory health, advocating for integrated approaches to patient care. For more details, see the original publication: Eun Seok Kang et al, Association of Metabolic Dysfunction‐Associated Steatotic Liver Disease With Sudden Sensorineural Hearing Loss Among Older Adults, Laryngoscope Investigative Otolaryngology, 2025. DOI: 10.1002/lio2.70156.