Ivermectin Shows Promise in Reducing Malaria Transmission in Large-Scale Trials

A groundbreaking study published in The New England Journal of Medicine reveals that administering ivermectin to entire populations significantly decreases malaria transmission rates, especially when combined with existing control strategies such as bed nets and insecticides. Conducted by the Barcelona Institute for Global Health (ISGlobal) in collaboration with other research centers, the BOHEMIA trial is the largest of its kind, involving over 20,000 participants across Kenya and Mozambique.

The trial assessed the safety and efficacy of a monthly dose of ivermectin (400 mcg/kg) given for three months at the beginning of the rainy season. In Kenya, the focus was on children aged 5–15, while in Mozambique, children under five were targeted. Results showed a 26% reduction in new malaria cases in Kenya, with ivermectin treatment being safe and well-tolerated, showing only mild side effects already known from treating neglected tropical diseases. Notably, children living farther from cluster borders or in areas with more effective drug delivery experienced greater declines.

The Mozambique trial faced logistical challenges due to Cyclone Gombe and a cholera outbreak, highlighting the importance of community engagement for success. The research also uncovered collateral benefits: reductions in skin infestations such as scabies and head lice, and fewer bed bugs in Kenya. These findings suggest that ivermectin can serve as a valuable complementary tool in malaria control, especially as insecticide resistance becomes a growing concern.

Expert opinions from the study emphasize ivermectin's potential to bolster existing strategies and contribute to eradication efforts. The WHO's vector control advisory group has reviewed the evidence and recommended further studies. With its well-known safety profile and unique mechanism of killing mosquitoes that feed on treated individuals, ivermectin offers a promising, innovative approach to combating malaria globally.

Source: https://medicalxpress.com/news/2025-07-ivermectin-lowers-malaria-infection-added.html