Mia's Feed
Medical News & Research

New Insights Into How Epstein-Barr Virus Protein EBNA-LP Alters DNA to Cause Cancer

New Insights Into How Epstein-Barr Virus Protein EBNA-LP Alters DNA to Cause Cancer

Share this article

Research reveals how Epstein-Barr virus protein EBNA-LP alters DNA structure in B cells, promoting cancer development. Discover the mechanisms behind viral-induced carcinogenesis and potential therapeutic targets.

2 min read

Scientists at The Wistar Institute have uncovered a crucial mechanism by which the Epstein-Barr virus (EBV), a widespread pathogen infecting over 90% of the global population, influences cellular DNA to promote cancer development. The study focuses on the viral protein EBNA-LP, revealing that it actively rewires the three-dimensional organization of host DNA within infected B cells. This process facilitates the unlocking of previously restricted genome regions, enabling abnormal gene activation that promotes oncogenic transformation.

Published in Nucleic Acids Research, the research shows that EBNA-LP interacts with YY1, a host protein responsible for maintaining DNA architecture. Using advanced mapping techniques like HiChIP, the team demonstrated that EBNA-LP disrupts normal DNA folding, effectively opening locked genomic 'doors' and allowing the transcription of genes that are usually inactive. This genome reprogramming shifts B cells into a more naive, stem-cell-like state, increasing their plasticity and susceptibility to malignant transformation.

Traditionally considered a helper protein, EBNA-LP is now shown to have a distinct and pivotal role in viral-induced carcinogenesis. The study also indicates that EBNA-LP works alongside other viral proteins, EBNA1 and EBNA2, targeting the same cellular processes to manipulate DNA structure. This multifaceted approach underscores how EBV utilizes multiple tools to ensure persistent infection and tumor formation.

Understanding how EBNA-LP reprograms host genomes provides valuable insight into viral oncogenesis and highlights potential therapeutic targets. Currently, treatments for EBV-related diseases mainly address symptoms, but this research opens avenues for developing strategies that directly target viral mechanisms. Furthermore, the findings suggest similar genome remodeling processes may underlie other types of cancer caused by genetic mutations, offering broader implications for cancer therapy.

By studying viral manipulation techniques, researchers gain a window into fundamental cellular processes. As Tempera emphasizes, viruses like EBV exploit existing cellular tools, and unraveling these interactions can lead to innovative approaches to treat or prevent virus-associated cancers.

Stay Updated with Mia's Feed

Get the latest health & wellness insights delivered straight to your inbox.

How often would you like updates?

We respect your privacy. Unsubscribe at any time.

Related Articles

Study Finds No Sex Differences in Autism Traits During Initial Diagnosis in Toddlers

A groundbreaking study reveals no significant sex differences in autism traits among toddlers at initial diagnosis, challenging previous assumptions and guiding future early intervention strategies.

Understanding Why Sleep Deprivation Exacerbates Migraine Symptoms

New research uncovers how sleep deprivation worsens migraine symptoms by impairing the brain's pain modulation mechanisms, emphasizing the importance of good sleep for migraine sufferers.

Hormonal Fluctuations Influence Brain Structure and Memory Function in Mammals

New research shows that hormone cycles influence brain structure and memory, revealing a dynamic link between endocrine rhythms and cognitive function in mammals.

Socio-Economic Disparities in Dementia Care in Quebec

A groundbreaking study uncovers significant socio-economic disparities in dementia care in Quebec, revealing unequal access and treatment outcomes despite universal healthcare. The research emphasizes the urgent need for equitable health policies.