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Personalized Exercise Programs Improve Health Outcomes for Neuromuscular Disease Patients

Personalized Exercise Programs Improve Health Outcomes for Neuromuscular Disease Patients

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A new study reveals that personalized home-based exercise programs combined with coaching significantly improve fitness and health outcomes for individuals with neuromuscular diseases.

2 min read

A recent study published in Neurology highlights the potential benefits of tailored exercise and coaching interventions for individuals living with neuromuscular diseases, conditions characterized by muscle weakness and degeneration. While a cure for these diseases remains elusive, this research suggests that personalized physical activity can significantly enhance patients' fitness and overall well-being.

The study examined a diverse group of 91 participants with conditions such as muscular dystrophies, post-polio syndrome, and Charcot-Marie-Tooth disease, all of which impact muscle strength and nerve function. These individuals reported common barriers to physical activity, including fatigue, pain, and muscle weakness, which often lead to sedentary lifestyles.

Led by Dr. Eric Voorn of Amsterdam University Medical Center, the investigation involved a six-month program where participants performed home-based aerobic exercises using stationary bikes, combined with professional coaching. Most workouts were low to moderate intensity, with some sessions at higher intensities facilitated through face-to-face or phone consultations with physical therapists. The coaching component focused on motivation, goal setting, and feedback, aimed at integrating sustained physical activity into daily routines.

Participants underwent maximum effort exercise tests at four intervals: at the start, immediately following the program, six months post-completion, and one year later. By measuring oxygen consumption during these tests, researchers assessed physical fitness. Results demonstrated that the exercise group experienced a notable increase in aerobic capacity, with an average oxygen utilization 2.2 ml/min/kg higher immediately after the program, equating to about a 10% improvement. Even one year later, the exercise participants maintained higher fitness levels—23.9 ml/min/kg compared to 20.9 ml/min/kg in the control group.

Importantly, the frequency of adverse events such as falls or pain was similar between both groups, indicating that the exercise regimen was safe for individuals with neuromuscular diseases. The study also acknowledged that the COVID-19 pandemic impacted participants' physical activity levels, which could influence outcomes.

This research emphasizes that structured, personalized exercise routines with professional support can be a safe and effective strategy to enhance physical health in populations with neuromuscular conditions. Future studies will explore how improved fitness translates to better daily functioning and how to motivate long-term adherence to physical activity.

Source: https://medicalxpress.com/news/2025-06-personalized-boosts-health-people-neuromuscular.html

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